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VU 0357121

CAS No. 433967-28-3

VU 0357121 ( VU-0357121, VU0357121, VU 0357121 )

Catalog No. M18548 CAS No. 433967-28-3

VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    VU 0357121
  • Note
    Research use only, not for human use.
  • Brief Description
    VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
  • Description
    VU0357121 is a positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Mutagenesis studies indicate that VU0357121 and related analogues bind to a yet uncharacterized allosteric site on mGlu(5), distinct from CPPHA, yet share a functional interaction with the MPEP site.
  • Synonyms
    VU-0357121, VU0357121, VU 0357121
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mGluR5
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    433967-28-3
  • Formula Weight
    305.32
  • Molecular Formula
    C17H17F2NO2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL; 163.76 mM
  • SMILES
    CCCCOc1ccc(cc1)C(=O)Nc1c(cc(cc1)F)F
  • Chemical Name
    4-Butoxy-N-(2,4-difluorophenyl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716.
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