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VU 0357121

CAS No. 433967-28-3

VU 0357121 ( VU-0357121, VU0357121, VU 0357121 )

Catalog No. M18548 CAS No. 433967-28-3

VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.

Purity : 98%

COA

Datasheet

HNMR

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MSDS

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10MG	78	In Stock
25MG	167	In Stock
50MG	332	In Stock
100MG	500	In Stock
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Biological Information

Product Name

VU 0357121
Note

Research use only, not for human use.
Brief Description

VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.
Description

VU0357121 is a positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Mutagenesis studies indicate that VU0357121 and related analogues bind to a yet uncharacterized allosteric site on mGlu(5), distinct from CPPHA, yet share a functional interaction with the MPEP site.
Synonyms

VU-0357121, VU0357121, VU 0357121
Pathway

Others
Target

Other Targets
Recptor

mGluR5
Research Area

Neurological Disease
Indication

——

Chemical Information

CAS Number

433967-28-3
Formula Weight

305.32
Molecular Formula

C17H17F2NO2
Purity

98%
Solubility

DMSO : ≥ 50 mg/mL; 163.76 mM
SMILES

CCCCOc1ccc(cc1)C(=O)Nc1c(cc(cc1)F)F
Chemical Name

4-Butoxy-N-(2,4-difluorophenyl)benzamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716.

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